Plain-English translation of NCT06144476 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our COPD research guide →Researchers at Guy's and St Thomas' NHS are studying how inflammation and other changes happen in people's lungs when they have asthma, COPD, or other airway diseases. By collecting samples like sputum, blood, and nasal secretions from both patients with lung disease and healthy volunteers, the team hopes to understand what makes some people's lungs healthy and what goes wrong in disease. This information could help doctors develop better treatments in the future.
Currently, doctors don't fully understand why some people develop asthma or COPD and what happens inside the lungs during these diseases. By studying the biological markers and physical characteristics of healthy and diseased lungs side by side, researchers aim to fill this knowledge gap and eventually improve how these conditions are diagnosed and treated.
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You would visit the research clinic at King's College London or Guy's and St Thomas' NHS Trust, typically once per year, for lung function tests, questionnaires, and sample collection (blood, sputum, and nasal samples). If you choose the optional bronchoscopy procedure, you would have a flexible camera gently passed into your lungs to collect additional samples. You may also be invited for extra visits if your condition changes or you receive new treatment. The entire study involves sharing samples and medical information over time to help researchers track how your lungs change.
AI-generated summary from trial data · Jun 17, 2026 · Not medical advice
United Kingdom
Sponsor
Guy's and St Thomas' NHS Foundation Trust
Collaborators
King's College London
Enrollment target
~230 participants
Started
February 2024
Primary completion
August 2026
Age range
18 Years and older
Last updated on clinicaltrials.gov in June 2026.
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Central contact
Gillian Radcliffe, MRes
GSTT and KCL
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.