Plain-English translation of NCT06145841 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This trial is testing whether a newer genetic sequencing technology called metagenomic next-generation sequencing can help doctors identify infections more quickly and accurately in people with advanced AIDS who have severe pneumonia or sepsis. Half the participants will receive this new genetic test along with standard infection tests, while the other half will receive only standard tests. The goal is to see if the new method helps doctors choose the right treatments faster.
People with advanced AIDS often get serious infections that are hard to identify using standard tests, which can delay treatment and be life-threatening. This study wants to know if the new genetic sequencing method can find infections faster and more accurately, helping doctors start the right treatment sooner.
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If you join this study, you will be assigned to either the new genetic testing group or the standard testing group. Both groups will have blood samples taken and will be monitored for four weeks, with follow-up visits at weeks 1, 2, 3, and 4 after your diagnosis. The main difference is that one group will have their blood tested using the new genetic sequencing method in addition to standard tests, while the other group receives only the standard tests. Doctors will track how quickly and accurately each method identifies your infection and guides your treatment.
AI-generated summary from trial data · Jun 9, 2026 · Not medical advice
China
Sponsor
Guangzhou 8th People's Hospital
Enrollment target
~400 participants
Started
October 2023
Primary completion
October 2026
Age range
18 Years – 65 Years
Last updated on clinicaltrials.gov in November 2023.
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