Plain-English translation of NCT06152406 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This study compares two ways of placing pacemaker leads in patients with atrial fibrillation (a condition where your heart beats irregularly) who are having a procedure to slow their heart rate. Half the participants will receive a traditional right ventricle pacemaker lead, while the other half will receive a newer type of lead placed on the HIS bundle, which is a special part of your heart's electrical system. The study wants to see if this newer placement method helps patients feel better and protects their heart function over one year.
Many patients with atrial fibrillation cannot take medications to restore a normal rhythm and instead need a pacemaker to control their heart rate. Traditional pacemakers can sometimes weaken the heart over time, so researchers want to test whether placing the lead in a different location — on the HIS bundle — might work better and be gentler on your heart.
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If you join this study, you will be randomly assigned to receive either the traditional pacemaker lead or the newer HIS bundle lead. You will have pacemaker implantation surgery, and your heart's electrical system will be deliberately slowed down (through a procedure called AV node ablation) either at the same time or a few weeks later. After that, you'll have follow-up visits at 4 weeks, 6 months, and 12 months to check how you're doing, with measurements of your heart function and your symptoms. You won't know which type of lead you received until the end of your 12-month follow-up.
AI-generated summary from trial data · Jun 5, 2026 · Not medical advice
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