Plain-English translation of NCT06152653 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Asthma research guide →Phase 4 — The treatment has already been approved. Researchers are tracking how it works in a large number of people over time.
This trial is testing whether using a special nebulizer system that adds gentle pressure while you breathe in N-acetyl cysteine (NAC)—a medication that breaks up thick mucus in your airways—works better than the standard way of delivering it. Researchers want to see if the added pressure helps the medication mix better with mucus plugs in your lungs and clear them more effectively. The study will compare this new delivery method to the traditional one in people with asthma or COPD who have visible mucus buildup in their lungs.
Many people with asthma and COPD struggle with thick mucus blocking their airways, which makes breathing harder. Doctors already use this medication to help clear mucus, but the standard way of delivering it may not work as well as it could—the medication doesn't always reach the blocked areas deeply enough.
If you join this study, you will be randomly assigned to receive the medication through either a standard nebulizer or the new pressure-assisted nebulizer system. Over 30 days, you will come in for 5 treatment visits, and at each visit you will receive two inhalation treatments (separated by 4 hours) of the medication mixed with a bronchodilator to help open your airways. The study staff will measure your lung function before and after treatment to make sure you're tolerating the medication well.
AI-generated summary from trial data · Aug 18, 2026 · Not medical advice
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