Plain-English translation of NCT06154915 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Researchers want to understand why some diabetic patients develop chronic foot ulcers that won't heal, while others don't. This study will collect blood samples and small tissue samples from foot ulcers at multiple visits over several months to analyze how your immune cells are working. By comparing patients whose ulcers are healing with those whose aren't, scientists hope to discover new ways to help wounds close and prevent serious complications like amputation.
Current treatments for diabetic foot ulcers don't work well enough—many patients still lose limbs despite antibiotics and surgery. Researchers believe the problem may be that high blood sugar changes how immune cells function in ways that prevent healing, even when diabetes is well-controlled. This study aims to pinpoint exactly what goes wrong so doctors can develop better treatments in the future.
You likely qualify if…
You likely don't qualify if…
You'll make three visits to the foot clinic over 2 to 3 months, spaced 4 to 8 weeks apart. At each visit, doctors will take blood samples and a small tissue sample (biopsy) from your foot ulcer, photograph the ulcer, and collect other routine measurements. You'll continue receiving your normal diabetic foot care from the medical team, which may include procedures like improving circulation or cleaning the wound. The study is observational—you're not taking any new medication; researchers are simply studying how your body's immune system is responding.
AI-generated summary from trial data · Jun 16, 2026 · Not medical advice
Sweden
Sponsor
Karolinska Institutet
Enrollment target
~40 participants
Started
September 2022
Primary completion
December 2027
Age range
18 Years – 98 Years
Last updated on clinicaltrials.gov in September 2025.
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Central contact
Eva Steninger
Karolinska Institutet
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.