Plain-English translation of NCT06163573 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing a new treatment called (nasal chondrocyte-based engineered cartilage implantation), which uses your own cartilage cells grown in the laboratory and implanted into your knee joint. The study will compare this new implant against a more established treatment called platelet-rich plasma (PRP) injections to see which one reduces knee pain more effectively over two years.
Patellofemoral osteoarthritis — wear-and-tear damage in the front part of the knee — is very common and affects quality of life for millions of people. Current treatments like PRP injections help some patients but not all, so researchers want to know if this new lab-grown cartilage implant can work better and possibly repair the damaged knee joint more permanently.
You likely qualify if…
You likely don't qualify if…
If you join this study, you will be randomly assigned to receive either the lab-grown cartilage implant (which requires a surgical procedure to place it in your knee) or a series of three PRP injections given one week apart. You will then attend follow-up visits at 6, 12, and 24 months to have imaging scans (X-rays and MRI) and complete questionnaires about your pain, activity level, and quality of life. You will also need to complete a rehabilitation program after your treatment to help your knee recover.
AI-generated summary from trial data · Jun 24, 2026 · Not medical advice
Croatia
Germany
Switzerland