Plain-English translation of NCT06163625 on ClinicalTrials.gov ↗ ·
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This study is testing how a treatment called repetitive transcranial magnetic stimulation (rTMS) changes brain activity in people with treatment-resistant depression — depression that hasn't improved with antidepressant medications. Researchers will use brain scans and to understand which people respond best to this magnetic brain stimulation and why, by looking at brain activity patterns and biological markers related to mood and reward.
Many people with depression don't get better with medication alone. Doctors know that rTMS can help some of these patients, but they don't fully understand how it works or why some people respond better than others. This study aims to identify the biological and brain-based factors that predict who will benefit from this treatment, so it can be better targeted in the future.
You likely qualify if…
You likely don't qualify if…
If you qualify, you'll be part of either a depression group receiving rTMS treatment or a healthy control group. Participants will complete detailed interviews about their mental health history, have brain scans taken before and after treatment, and provide for biological testing. The study collects information about how your depression symptoms change over time and relates these changes to your brain activity and biological markers.
AI-generated summary from trial data · Jun 2, 2026 · Not medical advice
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