Plain-English translation of NCT06174285 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Depression research guide →This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
Researchers have found that psychedelic substances can help with depression, but they want to understand exactly why — and whether the benefits come from the experience itself or the drug. This trial tests a virtual reality program called Psyrreal, designed to create similar experiences to psychedelics, to see if it can reduce depression symptoms without the actual drug.
Scientists know this medication shows promise for depression, but they don't fully understand how it works or whether the feeling of the experience is what helps patients recover. This study explores whether creating that experience through virtual reality alone — without the drug — might also be therapeutic.
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If you qualify, you'll be randomly assigned to one of three groups: some participants will use the Psyrreal virtual reality program (designed with psychedelic-like effects), others will use Routine Realms (a similar VR experience without those effects), and some may be placed on a waiting list. You'll complete the experience and have your depression symptoms measured before and after to see if the treatment helps.
AI-generated summary from trial data · Jul 5, 2026 · Not medical advice
Estonia