Plain-English translation of NCT06174389 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Obesity research guide →This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
The ADAPT Study is looking at what happens in your body when you lose weight—especially why weight loss often slows down or stops after a few months, even when you're still trying. You'll participate in a behavioral weight loss program (learning about diet and healthy habits) while researchers take measurements, blood samples, and brain images to understand the physical changes happening underneath.
Many people who lose weight hit a plateau where their body seems to resist further weight loss. Doctors don't fully understand why this happens or how to help people get past it. This research aims to identify the body's natural changes during weight loss so future treatments can be more effective.
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Over 18 months, you'll have three in-person study visits (and possibly three more) where you'll complete questionnaires, have blood drawn, get a brain MRI scan, have your body composition measured, and provide small tissue samples from muscle and fat. Between visits, you'll join a 6-month remote weight loss program focused on diet and behavioral changes, and you'll wear a provided fitness tracker and use a body weight scale at home to track your progress.
AI-generated summary from trial data · Jun 11, 2026 · Not medical advice
United States