Plain-English translation of NCT06175988 on ClinicalTrials.gov ↗ ·
Researchers want to understand why people with more belly fat often have changes in their sense of taste and smell, and why they may crave different foods. This pilot study will test whether the amount of fat around your digestive organs is connected to how your taste buds and nose work, and how much you enjoy or want certain foods. The study focuses on a nerve called the vagus nerve, which may be the link between belly fat and these food preference changes.
People with obesity often experience reduced sensitivity to taste and smell, and tend to prefer foods high in fat and sugar—but the reasons why aren't fully understood. If researchers can understand this connection, it may help develop better treatments for weight management and improve people's relationship with food.
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You will visit the research center for one investigative visit where researchers will measure your body composition and perform sensory tests. These tests will involve tasting different flavors (salt, sugar, sour, and bitter) and smelling various scents to assess how well your taste and smell work. Researchers will also collect information about your food preferences and may take measurements related to how your vagus nerve is functioning. The entire process is non-invasive and designed to understand the relationship between your body composition and sensory preferences.
AI-generated summary from trial data · Jun 2, 2026 · Not medical advice
Canada