Two-stage versus one-stage valve placement for severe lung disease

This study compares two different ways of using Zephyr® valves—small one-way devices placed inside your airways to help your lungs work better—in people with severe emphysema. Half of the participants will receive the valves in two separate procedures (two-stage), and the other half will have all the valves placed in a single procedure (one-stage). The main goal is to find out which approach leads to fewer dangerous air pockets in the lung (pneumothorax) while helping you breathe better.

Severe emphysema damages your lungs and makes breathing very difficult. Surgery to remove the damaged lung tissue works but carries serious risks. This medication offers a less invasive option, but doctors want to know the safest and most effective way to place the valves—whether doing it in stages or all at once is better for patients.