Testing a treatment plan for high-risk childhood blood cancer

Plain-English translation of NCT06184009 on ClinicalTrials.gov ↗ · Source last updated July 2026 · Translation generated June 2026 · How we translate trials

Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.

What is this trial?

This trial is testing a customized chemotherapy treatment plan for children and teens (ages 1–19) with newly diagnosed high-risk acute lymphoblastic leukemia (ALL). The treatment starts with chemotherapy, then doctors check how well the cancer is responding using special blood tests. Based on those results, your child may receive different combinations of chemotherapy to give them the best chance of remission while managing side effects thoughtfully.

High-risk ALL is aggressive and can be harder to treat, and standard one-size-fits-all approaches don't work equally well for all children. This study aims to improve outcomes by personalizing the chemotherapy plan—intensifying or adjusting it based on real-time evidence of how your child's body is responding to treatment.

Do you qualify?

You likely qualify if…

you are between 1 and 19 years old at the time of diagnosis
you have been newly diagnosed with pre-B acute lymphoblastic leukemia or T-cell acute lymphoblastic leukemia
you meet high-risk criteria, such as being 10 or older, having a high white blood cell count at diagnosis, or having certain genetic changes
you have not yet received chemotherapy (except possibly one intrathecal treatment) or steroids before enrolling
you may have cancer spread to the brain or testicles at diagnosis

You likely don't qualify if…

you have been diagnosed with Burkitt leukemia, mature B-cell leukemia, or Down syndrome
you are pregnant or have the potential to become pregnant without using adequate contraception during the trial
you have already received more than minimal chemotherapy or steroids for your newly diagnosed leukemia
you are currently enrolled in another drug or treatment trial

What participation looks like

Your child will receive chemotherapy in phases: an initial induction phase, followed by consolidation, then intensification cycles and maintenance therapy—the exact sequence depends on how the cancer responds to early treatment. Throughout the trial, doctors will perform regular blood tests (including special tests to measure remaining cancer cells) and check-up visits to monitor progress and decide whether to adjust the treatment plan. This is an active treatment study, so your family will be closely involved in medical care over several months to years.

AI-generated summary from trial data · Jun 24, 2026 · Not medical advice

Trial locations(9 sites)

South Korea

Seoul National University Hospital, Seoul, Seoul

Samsung Medical Center, Seoul, Seoul

Inha University Hospital, Incheon

Korea University Anam Hospital, Seoul

Severance Hospital, Seoul