Plain-English translation of NCT06184516 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing a new decision tool to help doctors figure out which women with bladder cancer can safely have their reproductive organs preserved during bladder removal surgery. Currently, doctors remove the bladder, uterus, ovaries, fallopian tubes, and part of the vagina as standard practice. This new tool could help avoid unnecessary removal of these organs when cancer risk to them is low.
Removing reproductive organs during bladder cancer surgery can cause serious side effects—including sexual problems, depression, bone loss, heart disease, and even increased risk of death in younger women. This trial exists to see if a careful evaluation method can identify which patients can safely skip this removal and avoid these harmful side effects while still treating their cancer effectively.
You likely qualify if…
You likely don't qualify if…
If you qualify, your doctor will use the new decision tool to evaluate your imaging scans and bladder examination results to determine whether you are a good candidate for organ-sparing surgery. Based on this evaluation, you will either have bladder removal surgery while keeping your reproductive organs, or standard bladder removal surgery with removal of those organs. You will need recent MRI scans of your pelvis and a cystoscopic exam (camera look inside your bladder) before surgery, and you will be followed over time to make sure you are doing well.
AI-generated summary from trial data · Jul 6, 2026 · Not medical advice
United States