Comparing two treatments for hard-to-reach liver tumors from colon cancer

This trial is testing and comparing two newer treatment options for people with colorectal cancer that has spread to the liver in locations near important blood vessels or bile ducts—places where traditional surgery or heat-based treatments are too risky. One approach uses electrical pulses to destroy tumor cells (irreversible electroporation, or IRE), while the other uses precise, targeted radiation (stereotactic body radiotherapy, or SBRT). The study will determine which treatment works better at controlling the cancer and has fewer side effects.

Currently, there is no clear best treatment for these anatomically challenging liver tumors that cannot be removed surgically or treated with heat-based methods. This trial exists to compare these two newer, less invasive options and help doctors choose the safest and most effective approach for future patients.