Plain-English translation of NCT06189859 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 3 — Testing in thousands of people, comparing the treatment against what doctors currently use. This is the last big step before approval.
This trial is testing two different electrical cutting techniques used during a minimally invasive endoscopic procedure called peroral endoscopic esophageal myotomy (POEM). POEM is a treatment for achalasia and similar swallowing disorders where the esophageal muscle doesn't relax properly. Researchers want to compare which electrical cutting method works better and is safer during this procedure.
During POEM procedures, doctors need to cut and separate tissue in a precise way. Two different electrical cutting modes are available, and doctors aren't sure which one produces better results with fewer complications. This trial will help determine which technique is most effective and safest for patients.
You likely qualify if…
You likely don't qualify if…
You would undergo the POEM procedure as planned, but the surgeon would use one of two electrical cutting techniques to separate the tissue. You would be randomly assigned to receive either the spray coagulation method or the newer Precisect method. After the procedure, you would likely have follow-up visits to monitor your recovery and assess how well the treatment worked.
AI-generated summary from trial data · Sep 24, 2026 · Not medical advice
Egypt
Phase
Large-scale testing
Sponsor
Cairo University
Enrollment target
~52 participants
Started
March 2024
Primary completion
July 2025
This trial's estimated completion date has passed — the record may not be fully up to date.
Age range
18 Years and older
Last updated on clinicaltrials.gov in May 2025.
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Central contact
hany Shehab, MD, FRCP
Cairo University
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.