Plain-English translation of NCT06190197 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 1 — Testing in a small group (usually 20–80 people) to find a safe dose and watch for side effects.
This trial is testing whether patients who have their bladder removed due to cancer need to take preventive antibiotics after surgery. Researchers are comparing two approaches: one group will receive the antibiotic nitrofurantoin after surgery to prevent infections, while the other group will only receive antibiotics if they develop an actual infection. The study will track which approach results in fewer urinary tract infections over the 90 days following surgery.
Bladder removal surgery carries a risk of urinary tract infections, and doctors traditionally give preventive antibiotics to all patients. However, this medication increases antibiotic resistance and may not be necessary for everyone, so researchers want to see if it's safe to skip routine preventive antibiotics and only treat infections when they actually occur.
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If you join this study, you will be randomly assigned to either receive preventive antibiotics after your bladder removal surgery or to receive standard care with antibiotics only if needed. Researchers will monitor you for 90 days after your surgery to track whether you develop any urinary tract infections. You'll need to attend follow-up appointments and report any symptoms of infection during this period.
AI-generated summary from trial data · Jun 13, 2026 · Not medical advice
United States