Plain-English translation of NCT06190847 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Researchers are investigating whether the balance of bacteria in your mouth (your oral microbiome) can predict how well chemoradiotherapy will work for advanced esophageal squamous cell cancer. You would provide saliva samples so scientists can analyze your mouth bacteria alongside your cancer treatment response. The goal is to find a new way to predict which patients will benefit most from this standard cancer treatment.
Chemoradiotherapy is an important treatment for esophageal cancer patients who cannot have surgery, but doctors currently lack reliable ways to predict who will respond well. Recent research suggests that the bacteria living in your mouth may influence how your body responds to cancer treatment, so studying this connection could help doctors personalize care and improve outcomes.
You would provide saliva samples for researchers to analyze your oral bacteria, likely at baseline and possibly at other timepoints during or after your chemoradiotherapy treatment. Your participation would involve standard cancer treatment (chemoradiotherapy) that your doctors have already recommended, plus the additional step of providing saliva samples. The study will track how well your treatment works and compare that to the bacteria found in your mouth samples.
AI-generated summary from trial data · Jul 1, 2026 · Not medical advice
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