How sinus health improves in young children with cystic fibrosis on new medication

This study looks at how a new medication called ivacaftor or elexacaftor/tezacaftor/ivacaftor affects sinus and smell problems in young children with cystic fibrosis. Researchers will compare children who start the medication to children who are not taking it, measuring changes in sinus health and the ability to smell over two years.

Children with cystic fibrosis often develop sinus disease and lose their sense of smell, which affects quality of life. This medication is known to help the lungs in cystic fibrosis, but doctors want to understand whether it also helps prevent or improve these sinus and smell problems early on.