Plain-English translation of NCT06191848 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Obesity research guide →Phase 4 — The treatment has already been approved. Researchers are tracking how it works in a large number of people over time.
This trial is testing a medication called to see if it can help people with obesity and knee arthritis. The study wants to know whether this medication can reduce the number of people who need knee replacement surgery. You would receive either the real medication or a placebo (a dummy injection with no active drug) once a week for 18 weeks.
Excess weight puts stress on the knees and makes arthritis worse, often leading to surgery. This medication might help by reducing weight and potentially protecting the joint, which could help people avoid or delay knee replacement.
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You would come to the study site regularly over 18 months (72 weeks). You would learn to give yourself a weekly injection under the skin, similar to how people with diabetes inject insulin. The dose would gradually increase over the first few weeks until reaching the target dose. You would have blood tests and check-ins to monitor your health, weight, and knee symptoms throughout the trial.
AI-generated summary from trial data · Jun 27, 2026 · Not medical advice
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