Plain-English translation of NCT06193252 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Parkinson Disease research guide →This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing whether a smartphone app can help people at high risk for Parkinson's disease increase their daily physical activity over 24 months. You would use the app to track and gradually build up your exercise—either aiming for a larger increase in activity or a smaller one, depending on which group you're randomly assigned to. The researchers want to see if more exercise might slow down or prevent Parkinson's disease from developing.
Parkinson's disease is growing rapidly, and treatments work best in early stages before the disease progresses too far. This study focuses on people with isolated REM sleep behavior disorder, which is a strong sign someone may develop Parkinson's disease later. The researchers believe that starting exercise early—before symptoms appear—might be more effective at slowing the disease than waiting until it fully develops.
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You would use a smartphone app for 24 months (two years) that tracks your daily steps and exercise. Half of participants will be encouraged to significantly increase their activity level, while the other half will make smaller increases. You'll also wear a fitness tracker, complete periodic assessments of symptoms and fitness through the app, and have optional MRI brain scans and blood tests to help researchers understand disease progression.
AI-generated summary from trial data · Sep 3, 2026 · Not medical advice
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