Plain-English translation of NCT06193499 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This study is testing whether high-concentration platelet rich plasma (PRP)—a treatment made from your own concentrated blood—can reduce pain and improve hand function in people with arthritis at the base of the thumb. Researchers will compare this injection to a placebo (salt water) injection to see if PRP truly makes a difference. You'll be tracked for 6 months after the injection to measure pain relief and how well your thumb works.
Thumb base arthritis is common and painful, limiting everyday activities like gripping and pinching. Currently, treatment options are limited, and doctors are searching for new ways to relieve pain and improve function without surgery. This study aims to find out if this medication—made from the patient's own blood—can offer real relief.
You likely qualify if…
You likely don't qualify if…
You will receive either the blood-derived injection or a placebo injection into your thumb base joint—you won't know which one you get. Before the injection and then at 3, 6, and 12 months afterward, you'll visit the clinic to report your pain level, describe how your thumb is functioning, and have your grip strength and thumb movement tested. The entire study takes about one year, with the main outcome measured at 6 months.
AI-generated summary from trial data · Jun 3, 2026 · Not medical advice
Sweden
Sponsor
Karolinska Institutet
Enrollment target
~90 participants
Started
January 2024
Primary completion
December 2026
Last updated on clinicaltrials.gov in June 2025.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Maria Wilcke, MD, PhD
Karolinska Institutet
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.