Plain-English translation of NCT06196190 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Researchers are studying whether a procedure called conization—removing a small cone of tissue from the cervix—followed by HPV (human papillomavirus) testing can help predict which women with early cervical cancer will have the best outcomes after surgery. This study will compare women who had this tissue removal procedure before surgery with those who went straight to surgery, and will track their HPV test results and cancer outcomes over time.
Some earlier research suggests that removing cervical tissue before surgery and then testing for HPV might help doctors identify which patients are at lower risk for cancer returning. However, no large prospective study has carefully examined this relationship, so researchers want to confirm whether this approach truly improves patient outcomes.
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You will be placed into one of four groups based on whether you had the tissue removal procedure (conization) before surgery and whether your HPV test came back positive or negative after the procedure. Researchers will review your medical records, pathology results, and HPV test results, and follow your health outcomes over time to see if the procedure and HPV status help predict whether cancer returns or complications develop.
AI-generated summary from trial data · Jun 13, 2026 · Not medical advice
Israel
Sponsor
Rambam Health Care Campus
Enrollment target
~200 participants
Started
July 2023
Primary completion
August 2026
This trial's estimated completion date has passed — the record may not be fully up to date.
Age range
18 Years – 85 Years
Sex
Female only
Last updated on clinicaltrials.gov in January 2024.
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Central contact
Yoav Siegler, MD
Rambam Health Care Center
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