Predicting which severe lung disease patients will have frequent flare-ups

Plain-English translation of NCT06198309 on ClinicalTrials.gov ↗ · Source last updated January 2024 · Translation generated June 2026 · How we translate trials

What is this trial?

This research study is looking for patterns that predict which patients with severe chronic obstructive pulmonary disease (COPD) will experience frequent flare-ups of their symptoms. Researchers will examine gut bacteria and use computer models to find warning signs that could help doctors predict and prevent these episodes in the future.

Currently, doctors have difficulty predicting which COPD patients will suffer from frequent flare-ups, making it hard to provide the right care at the right time. This study aims to develop a prediction tool that could help doctors identify high-risk patients earlier and find new treatment targets to improve their health.

Do you qualify?

You likely qualify if…

you have been diagnosed with severe COPD according to current medical guidelines (with specific lung function test results showing significant airway damage)
you are over 40 years old
your COPD has been stable for at least 4 weeks before enrolling
you have not used certain COPD medications in the required timeframe before the study (short-acting within 24 hours, long-acting within 48 hours, and no steroids in the past month)
you are willing to give informed consent and participate in the study

You likely don't qualify if…

you have asthma, active tuberculosis, severe lung scarring, or other serious lung conditions
you have serious health conditions like recent infections, uncontrolled diabetes, recent stroke, heart disease, liver or kidney problems, cancer, or autoimmune diseases
you have a history of chronic digestive problems or recent gut surgery
you have used antibiotics, probiotics, or oral steroids within the past 4 weeks
you are pregnant or breastfeeding

What participation looks like

You will be divided into two groups based on your history of flare-ups: those who experience frequent flare-ups and those who don't. Researchers will collect information about your medical history, lung function, and provide gut bacteria samples for analysis so they can identify patterns that predict future flare-ups. The study involves working with the research hospital team to gather this information.

AI-generated summary from trial data · Jun 2, 2026 · Not medical advice

Trial locations(1 site)

China

Beijing Chaoyang Hospital Affiliated to Capital Medical University, Beijing, Beijing Municipality