Testing a new cancer drug for cancers that stopped responding to previous treatment

Plain-English translation of NCT06199895 on ClinicalTrials.gov ↗ · Source last updated June 2025 · Translation generated June 2026 · How we translate trials

Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.

What is this trial?

This trial is testing , a new formulation of an existing cancer drug designed to treat advanced cancers that have become resistant to standard taxane chemotherapy. The study will enroll about 25 people with pancreatic, bile duct, lung, stomach, esophageal, or breast cancer who have not responded well to previous taxane treatment. Researchers want to see if this new medication can shrink tumors and help people live longer.

When certain cancers stop responding to standard chemotherapy drugs called taxanes, patients have few good options left. This trial exists to test whether this new form of the medication might be more effective for these drug-resistant cancers and offer hope to people who have already tried other treatments.

Do you qualify?

You likely qualify if…

you are 18 years or older
you have been diagnosed with advanced pancreatic, bile duct, lung, stomach, esophageal, or breast cancer confirmed by biopsy
your cancer stopped shrinking or came back after treatment with taxane chemotherapy, or it never shrank despite at least 2 cycles of taxane treatment
your overall health and major organ function (heart, lungs, liver, kidneys) are reasonably good
your blood counts and liver and kidney function tests meet certain minimum thresholds
you are expected to live at least 3 months

You likely don't qualify if…

you are allergic to paclitaxel or any ingredients in the medication
you have an active, untreated infection or uncontrolled hepatitis, or severe liver damage from cancer spread
you have large amounts of fluid around your lungs, heart, or abdomen that cannot be drained or controlled
you have severe heart or lung failure, bleeding disorders, or other serious organ damage that would make chemotherapy unsafe
you are pregnant, breastfeeding, or unwilling to use effective birth control during and for 6 months after treatment

What participation looks like

You would receive injections of the medication every three weeks in a cycle of treatment. You would continue receiving the medication as long as your cancer is not getting worse and you are tolerating the side effects well. Your doctors would monitor you regularly with blood tests and scans to check how your cancer is responding, and you would report any side effects you experience.

AI-generated summary from trial data · Jun 4, 2026 · Not medical advice

Testing a new cancer drug for cancers that stopped responding to previous treatment

What is this trial?

Do you qualify?

What participation looks like

Trial locations(1 site)