Plain-English translation of NCT06199921 on ClinicalTrials.gov ↗ ·
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing whether atorvastatin, a common cholesterol-lowering medication, can help improve tuberculosis treatment outcomes when added to standard TB drugs. Researchers believe that atorvastatin may help your immune system fight the tuberculosis bacteria more effectively, because the bacteria rely on cholesterol to survive and spread. The study will compare different doses of the medication alongside your regular TB treatment.
Current tuberculosis treatment is long, difficult to complete, and patients often relapse after finishing therapy. By adding this medication, researchers hope to shorten treatment time, improve cure rates, and prevent the lung damage and scarring that TB commonly causes.
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You would take your regular TB medications along with one of three possible doses of atorvastatin (or standard treatment only, if assigned to the control group) for the duration of your TB therapy. You'll have regular clinic visits for blood tests, sputum samples, and check-ups to monitor how well the treatment is working and watch for any side effects. The study involves about 440 participants across multiple sites.
AI-generated summary from trial data · Jun 3, 2026 · Not medical advice
Nigeria