Plain-English translation of NCT06200155 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This study is testing whether — a naturally occurring psychedelic compound — combined with professional psychological support can help reduce depression and anxiety in people with advanced cancer who are actively receiving cancer treatment. Researchers will compare the medication to a placebo (niacin, a B vitamin) to see if it improves mood, quality of life, and well-being. The study will also measure safety and look at how the treatment might affect brain function and immune markers.
Many people with advanced cancer experience significant depression and anxiety as they cope with their diagnosis and treatment. Current medications don't work well for everyone, so researchers are exploring whether this medication, paired with skilled psychological support, might offer a new way to help patients find relief and meaning during their cancer journey.
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If you join this study, you will receive either the medication or a placebo, combined with professional counseling sessions. You will take two doses of the treatment at MD Anderson Cancer Center, spaced about a week apart, and work with a trained therapist during these sessions. You will also complete several questionnaires about your mood, quality of life, and well-being before treatment, shortly after, and at follow-up visits over several months. The study team may also collect blood samples and brain imaging scans to measure how the treatment affects your immune system and brain activity.
AI-generated summary from trial data · Jul 5, 2026 · Not medical advice
United States
Phase
Testing effectiveness
Sponsor
M.D. Anderson Cancer Center
Collaborators
Gateway for Cancer Research
Enrollment target
~30 participants
Started
April 2024
Primary completion
December 2026
Age range
25 Years and older
Last updated on clinicaltrials.gov in July 2026.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Moran Amit, MD
M.D. Anderson Cancer Center
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.