Two radiation approaches for prostate cancer recurrence after surgery

Plain-English translation of NCT06205316 on ClinicalTrials.gov ↗ · Source last updated July 2026 · Translation generated July 2026 · How we translate trials

Phase 3 — Testing in thousands of people, comparing the treatment against what doctors currently use. This is the last big step before approval.

What is this trial?

This trial compares two types of radiation therapy for men whose prostate cancer has returned after surgical removal of the prostate. One approach uses very focused, high-dose radiation given quickly (5 treatments over 1–2 weeks), while the other uses smaller daily doses given over a longer period (20 treatments over 4–6 weeks). Researchers want to find out which method causes fewer serious side effects while controlling the cancer equally well.

After prostate removal surgery, some men's cancer comes back or spreads to a few spots. This trial exists because doctors need to know which radiation schedule is safest and works best—the faster, more intense approach or the slower, gentler approach.

Do you qualify?

You likely qualify if…

you have been diagnosed with prostate adenocarcinoma that has returned after surgery or has spread to a few sites (no more than 5 spots)
your PSA level is between 0.1 and 2.0 ng/mL, measured within 90 days before enrollment and at least 6 weeks after your prostatectomy surgery
you are at least 18 years old and in generally good health (ECOG performance status 0, 1, or 2)
you are able to start treatment within 120 days of enrolling in the study
you have not received prior radiation to the pelvis or chemotherapy for prostate cancer

You likely don't qualify if…

you have had previous radiation therapy to your pelvis
you have active inflammatory bowel disease (such as Crohn's disease or ulcerative colitis) affecting the rectum
you have had a heart attack or severe heart failure in the last 6 months
you have a history of urethral stricture that required stretching procedures
you have cancer that has spread to more than 5 sites in your body

What participation looks like

If you enroll, you will be randomly assigned to one of two radiation groups. The faster group receives 5 treatments over 1–2 weeks, while the other group receives 20 treatments spread over 4–6 weeks; each session lasts 15–20 minutes. You may also receive hormone therapy for up to 18 months if medically needed. Throughout the study, you will have blood tests, imaging scans (PET or MRI), and follow-up visits to track how you're doing and watch for any side effects. The study will monitor you for at least 5 years to measure how well the treatment works and its long-term effects.

AI-generated summary from trial data · Jul 12, 2026 · Not medical advice

Two radiation approaches for prostate cancer recurrence after surgery

What is this trial?

Do you qualify?

What participation looks like

Trial locations(6 sites)