Recruiting

Personalized cancer treatments matched to your tumor's genetic profile

Plain-English translation of NCT06208657 on ClinicalTrials.gov ↗ · Source last updated January 2026 · Translation generated June 2026 · How we translate trials

Phase 1/2 — A combined trial that checks safety and dosing while also starting to look at whether the treatment works.

What is this trial?

OPTIMISE is a trial that uses genetic testing of your child's or teen's cancer to match them with a targeted medication most likely to work against their specific tumor. The study offers different treatment options depending on what genetic changes are found in the cancer cells. This approach is called precision medicine — giving the right drug to the right patient based on their tumor's unique genetic profile.

Some childhood and adolescent cancers don't respond well to standard chemotherapy, and doctors need new ways to treat them. This trial exists to test whether matching medications to each patient's tumor genetics can help more young people survive cancer.

Do you qualify?

You likely qualify if…

you or your child has been diagnosed with a solid tumor, brain tumor, or lymphoma that has come back or isn't responding to standard treatment
you are under 21 years old at the time of enrollment (older teens and young adults may be included with approval)
you are already enrolled in a precision medicine genetic testing program like PROFYLE or Zero Childhood Cancer
you are well enough to participate in the study, with a performance status score of at least 50%
you have life expectancy of at least 6 weeks
your organs are functioning well enough to safely receive the study medication

You likely don't qualify if…

you have a brain tumor that is causing neurological problems or requires increasing doses of steroids to control
you have serious, uncontrolled heart problems or a recent history of heart disease
you have an active viral infection, HIV, or hepatitis that is not controlled
you have severe stomach or bowel problems that would prevent you from taking oral medications safely
you had major surgery within the 3 weeks before starting the study drug

What participation looks like

If your child is accepted into the trial, they will receive one of several personalized medication combinations tailored to their tumor's genetic profile. Treatment cycles typically last 28 days and may continue for up to 6 months or longer, depending on how well the medication is working. Your child will have regular clinic visits for blood tests, imaging scans, and check-ups to monitor how they're responding and watch for any side effects.

AI-generated summary from trial data · Jun 4, 2026 · Not medical advice

Trial locations(14 sites)

Australia

John Hunter Children's Hospital, Newcastle, New South Wales

Sydney Children's Hospital, Randwick, Sydney, New South Wales

The Children's Hospital at Westmead, Sydney, New South Wales

Queensland Children's Hospital, Brisbane, Queensland

Women's and Children's Hospital, Adelaide, South Australia