Plain-English translation of NCT06209359 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Heart Failure research guide →Phase 1 — Testing in a small group (usually 20–80 people) to find a safe dose and watch for side effects.
This trial is testing , a medication that might help your body respond better to loop diuretics (water pills) if you have heart failure and have developed resistance to them. Some people with heart failure find that their water pills stop working as well over time, making it harder to remove excess fluid. Researchers want to see if can restore your body's sensitivity to these lifesaving medications.
When people with heart failure take water pills for a long time, their bodies sometimes become 'resistant'—meaning the medication doesn't work as well at removing fluid, even at higher doses. This study exists to understand why this happens and whether the medication being tested can help reverse this resistance and make water pills effective again.
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You will visit the study site multiple times over about three weeks. During your first visit, researchers will test how your body responds to a water pill injection to confirm you have diuretic resistance. You'll then follow a special study diet and take either the study medication or a placebo twice daily, along with your regular water pill as an IV injection. You'll have blood drawn and provide urine samples to help researchers understand how the medication affects your body. After a 10–28 day break, you'll repeat the same process with the other treatment (medication or placebo) to compare the results.
AI-generated summary from trial data · Jun 19, 2026 · Not medical advice
United States
Phase
Safety & dosing
Sponsor
Yale University
Collaborators
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Enrollment target
~50 participants
Started
July 2024
Primary completion
March 2029
Age range
18 Years and older
Last updated on clinicaltrials.gov in May 2026.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Veena Rao, PHD
Yale University
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.