Plain-English translation of NCT06212791 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
EXCLAMATORY is a research study that tracks how your heart responds to a procedure called catheter ablation, which is used to treat paroxysmal atrial fibrillation (an irregular heartbeat condition). The study uses specialized heart imaging and exercise testing to see how well your heart chambers work — both at rest and during physical activity — before and after your ablation procedure. Researchers want to understand whether this procedure improves how your heart pumps blood and how much exercise you can do.
Ablation is a common treatment for irregular heartbeat, but doctors don't yet fully understand how the procedure affects the heart's overall performance during everyday activities and exercise. This study aims to fill that gap by carefully measuring changes in heart function, which could help doctors predict which patients will benefit most from this treatment.
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You would be followed over time as a participant in this study. Before your ablation procedure, you'll complete heart imaging scans (using a specialized MRI machine) and an exercise test to measure your heart's function and fitness level. After your ablation, you'll repeat these same tests to see how the procedure changed your heart's performance. The study involves regular visits to the hospital or clinic, though the exact number and timing of visits will be explained during the enrollment process.
AI-generated summary from trial data · Jun 7, 2026 · Not medical advice
United States
Sponsor
Virginia Commonwealth University
Collaborators
National Heart, Lung, and Blood Institute (NHLBI)
Enrollment target
~50 participants
Started
December 2024
Primary completion
March 2028
Age range
18 Years and older
Last updated on clinicaltrials.gov in March 2026.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Pamela Grizzard
Virginia Commonwealth University
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.