Plain-English translation of NCT06213857 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Ulcerative Colitis research guide →Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing whether silymarin—a natural extract from milk thistle plants—can help reduce inflammation in ulcerative colitis when taken alongside your regular medications. You would take silymarin along with two standard ulcerative colitis medicines ( and ) for three months. The researchers want to see if this medication helps calm down the inflammation that causes bleeding, diarrhea, and pain.
Ulcerative colitis causes ongoing inflammation of the colon and rectum that can be hard to control, even with current treatments. This medication is being studied because it may help reduce the harmful inflammatory molecules that damage the intestines.
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You would take silymarin (140 mg daily) along with your regular ulcerative colitis medications ( and ) for three months. The study compares this combination to the standard medications alone. You would likely have clinic visits to check how you're doing, provide blood samples, and track your symptoms during the three-month treatment period.
AI-generated summary from trial data · Jun 5, 2026 · Not medical advice
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