Plain-English translation of NCT06217198 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Depression research guide →This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing Deprexis, an online program designed to help treat depression. You would use this self-guided internet tool on your own computer, tablet, or smartphone to work through lessons and activities aimed at improving your mood and how well you're able to function day-to-day. The study wants to see whether this treatment works as well as or better than the standard care you would normally receive through the VA.
Depression is very common among veterans and can lead to serious problems like long-term disability and increased suicide risk. Many veterans struggle to get mental health treatment because of stigma, limited availability of appointments, or difficulty fitting sessions into their schedule. This medication is being studied because it could be a more accessible way to treat depression—available anytime, anywhere—without requiring you to travel to an office or take time off work.
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If you're selected for the study, you'll be randomly assigned to either receive Deprexis or to continue with your usual VA care. If you're in the Deprexis group, you'll log into the online program at your own pace and work through self-guided lessons and activities on topics like managing your thoughts and improving daily activities. The study team will track how your depression and functioning improve over time by having you complete questionnaires at different points during the study.
AI-generated summary from trial data · Jun 5, 2026 · Not medical advice
United States