Adding a B vitamin supplement to anxiety medication

This is a small pilot study testing whether L-methylfolate, a form of B vitamin, can help people with generalized anxiety disorder (GAD) whose symptoms haven't improved enough with standard anxiety medications. You would take the medication alongside the anxiety drug you're already using. The researchers want to see if this combination works better than medication alone.

About half of people with GAD don't get enough relief from their first anxiety medication. Researchers think this might be because some people don't have enough folate (a B vitamin) in their blood, or because inflammation in the brain isn't being addressed. Studies in depression suggest that adding this vitamin supplement might help more people improve.