Receive a new type of fluorescent dye injection during liver cancer surgery

Recruiting

What is this trial?

This trial is testing a new version of Indocyanine Green (ICG)—a special fluorescent dye mixed with human albumin—to help surgeons see liver tumors more clearly during minimally invasive (laparoscopic) cancer surgery. The medication glows under special lights in the operating room, helping doctors identify exactly which parts of the liver to remove. Researchers want to know if this new mixture works better than the standard ICG method currently used.

During liver cancer surgery, surgeons need to see the cancer clearly and remove it safely while protecting as much healthy liver as possible. The standard fluorescent dye works, but this new treatment may provide better, clearer images that could help surgeons do their job more precisely and reduce complications.

Do you qualify?

You likely qualify if…

you are between 18 and 75 years old
you have been diagnosed with liver cancer and need laparoscopic surgery to remove it
your liver function is rated Child-Pugh grade A or B (meaning your liver is working reasonably well)
your blood counts are normal or nearly normal (white blood cells, platelets, and hemoglobin within safe ranges)
you have an ECOG performance score of 0 or 1 (meaning you are active and able to care for yourself)

You likely don't qualify if…

you have poor liver function (ICG R15 score of 20% or higher)
you are allergic to ICG dye
you have serious heart or lung disease that would make surgery too risky
you have active bleeding or blood clotting problems
you have severe esophageal or stomach varices (enlarged veins that bleed easily) or have bled from your stomach in the past 6 months

What participation looks like

If you qualify and enroll, you will be randomly assigned to either receive the new medication mixture or the standard dye during your scheduled liver cancer surgery. The medication is injected into your vein during the operation after your surgeon blocks blood flow to the target area of liver. Your surgery will proceed with surgeons using the fluorescent light to guide their work. You will be monitored during your hospital stay, and researchers will track your recovery, how much blood you lost, how long surgery took, and whether you develop any complications.

Testing a new fluorescent dye mixture to guide liver cancer surgery

What is this trial?

Do you qualify?

What participation looks like

Trial locations(1 site)