Recruiting

Testing a new cancer treatment for stomach, pancreas, and bile duct cancers

Plain-English translation of NCT06219941 on ClinicalTrials.gov ↗ · Source last updated July 2026 · Translation generated August 2026 · How we translate trials

Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.

What is this trial?

This trial is testing a new medication called to see if it can help people with advanced cancers of the stomach, pancreas, bile ducts, and the junction between the stomach and esophagus. The study will test the medication both on its own and combined with standard chemotherapy drugs. Researchers want to understand whether this treatment is safe and how well it works against these types of cancer.

These cancers are difficult to treat and many patients don't respond well to standard therapies. This medication is designed to target a specific marker (claudin 18.2) found on these cancer cells, which may offer a new treatment option for patients who need more effective options.

Do you qualify?

You likely qualify if…

you are 18 years or older
your cancer cells test positive for claudin 18.2
you have at least one measurable tumor that can be seen on imaging
you are in good enough health to handle treatment (ECOG performance status 0–1)
you are expected to live at least 12 weeks
you weigh more than 35 kilograms (about 77 pounds)

You likely don't qualify if…

you have active bleeding in your digestive tract or a history of bleeding from prior claudin 18.2 therapy
you have large amounts of fluid in your abdomen that require drainage
you have cancer that has spread to your brain or brain disease
you have severe nerve damage (grade 2 or worse)
you have a history of severe lung inflammation or scarring (drug-induced pneumonitis)

What participation looks like

You would visit a cancer center regularly to receive the medication intravenously (through an IV). Depending on which part of the trial you join, you would receive either the new medication alone or combined with chemotherapy. You would have blood tests, imaging scans, and check-ups to monitor how well the treatment is working and watch for any side effects. The exact schedule and duration depend on which cancer type you have and how your cancer responds to treatment.

AI-generated summary from trial data · Aug 16, 2026 · Not medical advice

Trial locations(52 sites)

United States

Research Site, Orange, California

Research Site, Palo Alto, California

Research Site, Santa Rosa, California

Research Site, Louisville, Kentucky

Research Site, Commack, New York