Plain-English translation of NCT06221254 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Crohn Disease research guide →This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing COBMINDEX, a smartphone application designed to help people with Crohn's disease manage stress, pain, and emotional wellbeing through techniques like mindfulness, cognitive-behavioral therapy, and breathing exercises. You'll be randomly assigned to either learn these techniques from a human therapist for the first three months and then practice on your own using the app, or learn directly from the app itself. The study lasts 12 months total and tracks how well this treatment works for your physical and emotional health.
Living with Crohn's disease can be emotionally and physically challenging, and stress often makes symptoms worse. This trial wants to understand whether using digital mental health tools can be as helpful as working with a human therapist, and whether this treatment improves wellbeing and reduces the burden of the disease.
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The study lasts 12 months. In the first 3 months, you'll be randomly assigned to either learn stress-reduction techniques from a human therapist-social worker or learn them directly through the smartphone app. After that, everyone practices the techniques daily using the app for the remaining 9 months, with different levels of access depending on your group. Throughout the year, you'll answer daily questions about your stress, pain, fatigue, and wellbeing, and have regular check-ins where doctors assess your physical health, emotional wellbeing, and immune function.
AI-generated summary from trial data · Jun 2, 2026 · Not medical advice
Israel