Plain-English translation of NCT06221488 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study is tracking healthcare workers in Cape Town, South Africa who are at high risk of tuberculosis (TB) infection. Researchers will perform blood tests every 3 months for one year to better understand how TB infection develops, persists, or clears in the body—and to identify which people are most likely to develop active TB disease in the future.
Current TB infection tests cannot tell the difference between someone who is actively infected versus someone whose body has already cleared the infection. This study aims to fill that gap by closely monitoring how TB infection changes over time in healthcare workers, who face high exposure to TB in their daily work.
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You would visit the study clinic every 3 months for one year to have your blood drawn and tested for TB infection using established and newer blood tests. The researchers will also collect blood samples to store in a biobank for future research. In total, you would have approximately four visits over the 12-month period.
AI-generated summary from trial data · Jul 14, 2026 · Not medical advice
South Africa
Collaborators
University of Stellenbosch
Enrollment target
~300 participants
Started
January 2024
Primary completion
December 2028
Age range
18 Years – 100 Years
Last updated on clinicaltrials.gov in July 2026.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Ruvandhi Nathavitharana, MBBS MPH
Beth Israel Deaconess Medical Center
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.