Plain-English translation of NCT06223880 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Major Depressive Disorder research guide →Phase 4 — The treatment has already been approved. Researchers are tracking how it works in a large number of people over time.
This trial is testing whether , a new medication, can help prevent depression from coming back after you've started feeling better. The study compares this medication to another antidepressant called to see which one is more effective at keeping depression away over time. You would first take the new treatment to see if it helps your depression improve, and if it does, you'd then be randomly assigned to continue with it or switch to the comparison medication for the next 6 months.
Depression often comes back after people start feeling better, and finding the best medication to prevent relapse is important. This trial is testing whether this medication works better than a standard antidepressant at keeping depression from returning.
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You would start by taking the new medication twice daily for 10 weeks while doctors monitor how well it works for you. If your depression improves enough during this time, you would then be randomly assigned to either keep taking the same medication or switch to a comparison medication for the next 26 weeks. Throughout the study, you would have regular visits with the research team to track your mood and any side effects.
AI-generated summary from trial data · Jun 23, 2026 · Not medical advice
United States