Plain-English translation of NCT06225011 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 1 — Testing in a small group (usually 20–80 people) to find a safe dose and watch for side effects.
Researchers are studying whether , a medication commonly used to treat depression, might help your immune system fight colorectal cancer more effectively. The study focuses on understanding how this medication changes the immune cells inside your tumor before surgical removal. This is an early-stage trial with a small group of patients to see if this approach is safe and shows promise.
Scientists have noticed that certain antidepressants may influence how your immune system responds to cancer. This trial explores whether using this medication in the weeks before surgery could prepare your body's defense system to better recognize and fight cancer cells.
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If you join this trial, you will take the medication by mouth once daily for 10 days leading up to your scheduled colorectal cancer surgery. Researchers will collect tissue samples during your surgery to examine how the medication changed the immune cells in your tumor. The main commitment is taking the medication as prescribed before your operation, which you would likely be having anyway.
AI-generated summary from trial data · Jun 12, 2026 · Not medical advice
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