Plain-English translation of NCT06225011 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 1 — Testing in a small group (usually 20–80 people) to find a safe dose and watch for side effects.
Researchers are testing whether , a medication commonly used to treat depression, might help your immune system fight colorectal cancer more effectively. The study will examine how this medication changes the immune cells in your tumor before you have surgery to remove it. This is an early-stage trial with just 10 participants to see if this approach is safe and shows promise.
Scientists have noticed that serotonin (a brain chemical) may play a role in how well your immune system can fight cancer. This medication affects serotonin levels, so researchers want to see if it could boost your body's natural cancer-fighting abilities before surgery.
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You would take the medication by mouth once daily for 10 days before your scheduled surgery. During this time, researchers will monitor you to make sure the medication is safe and you're tolerating it well. When you have your surgery, doctors will examine the tumor tissue to see how the immune cells have changed, which is the main goal of the study.
AI-generated summary from trial data · Aug 24, 2026 · Not medical advice
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