Plain-English translation of NCT06228963 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing whether a medication called orelabrutinib, when combined with standard antibiotics that kill the bacteria causing the lymphoma, works better than antibiotics alone. The study focuses on people who have a rare type of stomach lymphoma linked to a Helicobacter pylori infection. Researchers want to see if adding this medication helps more patients recover.
Currently, doctors treat this type of lymphoma by giving antibiotics to eliminate the bacterial infection, and many patients do recover. However, some patients don't respond well to antibiotics alone, so researchers are testing whether the new treatment can help more people—particularly those whose lymphoma might not go away with standard care alone.
You likely qualify if…
You likely don't qualify if…
If you join this trial, you will be randomly assigned to one of two groups: one group receives antibiotics plus the new medication (orelabrutinib), and the other receives antibiotics alone. You will need to visit the clinic for check-ups, blood tests, and possibly endoscopies to see how well your treatment is working. The study will track how you respond over time to determine whether the new medication improves outcomes.
AI-generated summary from trial data · Aug 5, 2026 · Not medical advice
China
Phase
Testing effectiveness
Sponsor
Fudan University
Enrollment target
~160 participants
Started
March 2024
Primary completion
January 2026
This trial's estimated completion date has passed — the record may not be fully up to date.
Age range
18 Years and older
Last updated on clinicaltrials.gov in February 2024.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Yizhen Liu, M.D., Ph.D.
Fudan University
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.