Intensive Physical Therapy to Improve Walking in Hereditary Spastic Paraparesis

This study is testing whether adding extra physical therapy sessions to usual care can help people with SPG4 hereditary spastic paraparesis (a genetic condition affecting walking) improve their walking speed and function. The trial compares two groups: one that receives their normal weekly therapy plus 3 additional sessions per week for 6 weeks, and one that continues with usual care alone. The extra sessions include stretching, posture work, muscle strengthening, and balance exercises delivered either in-person or by video.

Earlier research by this team found that patients felt physical therapy was the most helpful treatment for their symptoms, especially when done frequently. This trial wants to confirm whether adding more sessions—3 extra times per week—really does help people walk better, which would make a real difference in their daily lives.