Plain-English translation of NCT06232772 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Parkinson's Disease research guide →Researchers are testing a new diagnostic method that analyzes skin samples and body fluids to detect a protein called alpha-synuclein, which builds up abnormally in Parkinson's disease. Currently, diagnosing Parkinson's accurately can be difficult and takes a long time, leading to missed or delayed diagnoses in about 20% of cases. This study aims to see if this simple, minimally invasive test can help doctors identify the disease much earlier.
Parkinson's disease and related conditions are hard to diagnose in their early stages because symptoms overlap with other diseases. Right now, the only way to confirm these diagnoses with certainty is through brain tissue biopsy, which is invasive and rarely done. This trial exists to create a better, easier alternative that could catch these diseases sooner, when treatment is most effective.
You likely qualify if…
You likely don't qualify if…
If you participate, researchers will collect a tiny skin sample (about 1mm) and body fluid samples like blood or cerebrospinal fluid. These samples will be tested using specialized laboratory methods to measure alpha-synuclein levels. You will likely visit the research center once or a few times for sample collection, and the procedure is minimally invasive—much simpler than a brain biopsy. The study involves about 600 participants total across multiple medical centers.
AI-generated summary from trial data · Jun 10, 2026 · Not medical advice
China
Sponsor
Yousheng Xiao
Collaborators
The First Affiliated Hospital of Guangzhou Medical University, First Affiliated Hospital, Sun Yat-Sen University
Enrollment target
~600 participants
Started
March 2024
Primary completion
June 2026
This trial's estimated completion date has passed — the record may not be fully up to date.
Age range
18 Years – 80 Years
Last updated on clinicaltrials.gov in April 2025.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Yousheng Xiao, professor
Guangxi Medical University
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.