Plain-English translation of NCT06235203 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 3 — Testing in thousands of people, comparing the treatment against what doctors currently use. This is the last big step before approval.
This trial is testing the best order and timing of treatments for people whose nasopharyngeal cancer (a cancer in the back of the nose and throat) has come back after previous radiation therapy. You would receive a combination of chemotherapy, immunotherapy, and endoscopic surgery (a minimally invasive surgical approach). The study compares two approaches: giving chemotherapy before surgery versus giving surgery first and then chemotherapy and immunotherapy afterward.
When nasopharyngeal cancer returns after radiation, doctors need to figure out the most effective way to combine surgery with chemotherapy and immunotherapy to give patients the best chance of recovery. This trial will help determine whether starting with chemotherapy before surgery improves outcomes compared to the current standard approach.
You likely qualify if…
You likely don't qualify if…
If you join this trial, you will be randomly assigned to one of two groups. One group will receive 2 rounds of chemotherapy before undergoing endoscopic surgery, followed by additional chemotherapy and immunotherapy sessions. The other group will have surgery first, followed by chemotherapy and immunotherapy. You will need to attend multiple visits for treatments, blood tests, and scans to monitor how you're responding. The entire treatment period will span several months, and you'll be closely monitored by the research team throughout.
AI-generated summary from trial data · Jun 13, 2026 · Not medical advice
China