Plain-English translation of NCT06238700 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Depression research guide →This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
Researchers believe that depression in midlife women may be linked to changing hormone levels during the transition to menopause. This study tests pregnenolone, an over-the-counter dietary supplement, to see if it can help reduce depression symptoms and help scientists understand how hormones affect mood during this life stage. You would take the medication (or a placebo) twice daily for four weeks while researchers measure changes in your mood and collect information about how your brain responds.
Many women experience depression during midlife, and scientists think this may be caused by natural drops in certain hormones during the menopause transition. This trial aims to understand that connection better and test whether this medication could be a helpful treatment option.
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You would take either the supplement or a placebo pill twice a day for four weeks. Throughout the study, you would complete assessments measuring your depression symptoms and participate in evaluations to help researchers understand how the medication affects your mood and brain function. The study involves regular check-ins where researchers will ask questions about your symptoms and may conduct tests to monitor your health and safety.
AI-generated summary from trial data · Jun 20, 2026 · Not medical advice
United States
Sponsor
Beth Israel Deaconess Medical Center
Enrollment target
~80 participants
Started
May 2024
Primary completion
July 2027
Age range
40 Years – 60 Years
Sex
Female only
Last updated on clinicaltrials.gov in May 2026.
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Central contact
Aleta Wiley, MPH
Columbia University
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