Recruiting

Ultrasound-Guided Injection vs. Surgery for Carpal Tunnel Syndrome

Plain-English translation of NCT06243848 on ClinicalTrials.gov ↗ · Source last updated March 2026 · Translation generated June 2026 · How we translate trials

This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.

What is this trial?

This trial is testing whether an ultrasound-guided injection of dextrose around the median nerve works as well as traditional minimally invasive surgery for treating carpal tunnel syndrome. Carpal tunnel syndrome causes numbness, tingling, and pain in your hand because a nerve in your wrist is being squeezed. Researchers want to see if the injection treatment can relieve your symptoms without requiring surgery.

Carpal tunnel syndrome is very common, and while both injections and surgery can help, doctors don't have strong evidence about which treatment works better or is safer. This study aims to compare these two approaches directly so patients and doctors can make better treatment choices.

Do you qualify?

You likely qualify if…

you have had hand numbness, tingling, or pain (especially at night) in the area supplied by the median nerve for more than three months
you have been diagnosed with mild, moderate, or severe carpal tunnel syndrome confirmed by nerve testing
you experience numbness and weakness in your hand, particularly in your thumb and palm area
you have tested positive on physical exams like the Phalen test or Tinel sign

You likely don't qualify if…

you have had a carpal tunnel injection in the past six months
you have had carpal tunnel surgery before
you have visible shrinkage or wasting of the muscle at the base of your thumb
you have an autoimmune condition such as rheumatoid arthritis, lupus, or systemic sclerosis
you are pregnant

What participation looks like

If you join this study, you will be randomly assigned to receive either an ultrasound-guided injection or minimally invasive surgery. With the injection, a doctor will use ultrasound imaging to guide a needle to the right spot and inject a dextrose solution around your median nerve. With surgery, you will have a small incision in your wrist and the surgeon will release the pressure on your nerve. You will be monitored after your treatment to see how well it works for relieving your symptoms.

AI-generated summary from trial data · Jun 4, 2026 · Not medical advice

Trial locations(1 site)

Turkey (Türkiye)

Afyonkarahisar Health Sciences University, Afyonkarahisar