Plain-English translation of NCT06245109 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 4 — The treatment has already been approved. Researchers are tracking how it works in a large number of people over time.
Researchers at Northwestern University want to understand why some people with knee osteoarthritis feel better with certain pain treatments and others don't. This 20-week study will test three different daily treatments — , , and a placebo — in people with knee arthritis pain. The goal is to identify specific signs in your body and brain that predict which treatment will work best for you.
Right now, doctors often prescribe pain medications by trial and error, which means patients may suffer through weeks or months of ineffective treatment. This study aims to find biological markers that can predict in advance which medication will actually help each individual person, so doctors can make smarter treatment choices faster.
You likely qualify if…
You likely don't qualify if…
You'll take one daily tablet (either , , or placebo) for about 20 weeks. You'll visit Northwestern University Feinberg School of Medicine for clinic appointments and rate your pain regularly throughout the study. Researchers will also collect brain imaging and blood or tissue samples to identify biological markers that show how your body responds to the treatment.
AI-generated summary from trial data · Jun 3, 2026 · Not medical advice
United States