Plain-English translation of NCT06249347 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Atrial Fibrillation research guide →This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing a treatment called PROMISED for people with persistent atrial fibrillation (a serious irregular heartbeat that lasts more than a week). The treatment combines radiofrequency ablation—a procedure that uses heat to scar and block abnormal electrical signals in the heart—with implantation of a small device that seals off a pouch in the heart called the left atrial appendage. Researchers believe this combination may work better than ablation alone and may also reduce stroke risk.
Persistent atrial fibrillation is hard to treat with ablation alone, and standard blood thinners don't work for everyone or aren't safe for all patients. This trial tests whether combining ablation with a device that closes off part of the heart can improve success rates and protect people from stroke more effectively.
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You will undergo an ablation procedure where doctors guide a catheter (thin tube) into your heart to use radiofrequency energy to scar tissue causing the irregular rhythm. If your heart rhythm doesn't return to normal after this first step, you will receive additional ablation in other areas of the heart. You will then have a device implanted to seal off a pouch in your heart. The entire procedure is done during one hospital visit, and you will be monitored afterward to check that the treatment is working and that you are healing well.
AI-generated summary from trial data · Jul 16, 2026 · Not medical advice
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