Plain-English translation of NCT06250985 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 3 — Testing in thousands of people, comparing the treatment against what doctors currently use. This is the last big step before approval.
When a heart device (like a pacemaker) becomes infected, doctors must remove it. This trial is testing whether it's safer to put a new device back in during the same procedure, or whether it's better to wait until the infection has fully cleared and then do a second procedure later. The study will follow 176 patients for 6 months to see which approach has fewer serious complications.
Currently, doctors typically wait to replace an infected heart device until the infection has completely cleared, which means patients go without their device for weeks or months. This trial exists to find out whether immediate replacement—once the infection has stabilized with antibiotics—might actually be safer and reduce complications.
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If you join this study, you will be randomly assigned to one of two groups: either your new device will be put in right away during the same surgery when your infected device is removed, or you will wait for a second procedure after your infection has fully cleared. Either way, you'll be closely monitored with blood tests, physical exams, and follow-up visits over the next 6 months to check for any new infections or complications.
AI-generated summary from trial data · Oct 7, 2026 · Not medical advice
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