Plain-English translation of NCT06252142 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study is following patients with locally advanced rectal cancer who have completed chemotherapy and radiation therapy and are choosing the "watch and wait" approach instead of surgery. Researchers will track how well the treatment worked, monitor any side effects, and check in on your quality of life over at least two years. This helps doctors understand whether this non-surgical approach is safe and effective for patients whose tumors have shrunk significantly after treatment.
Some patients with advanced rectal cancer experience complete tumor shrinkage after chemotherapy and radiation, which raises the question: do all of these patients still need surgery? This study exists to carefully monitor patients who choose to skip surgery and see how they fare over time, helping doctors better understand when the watch-and-wait approach is the right choice.
You likely qualify if…
You likely don't qualify if…
You will not receive any new treatment in this study—instead, researchers will follow your progress after you've finished chemotherapy and radiation. You'll attend regular follow-up visits according to standard care guidelines, where doctors will monitor how your body has responded to treatment, check for any side effects, and ask you to complete questionnaires about your quality of life. This close monitoring will continue for at least two years after your treatment ends, either through in-person visits or telephone check-ins if you're unable to visit the clinic.
AI-generated summary from trial data · Jul 9, 2026 · Not medical advice
India
Sponsor
Tata Memorial Centre
Enrollment target
~260 participants
Started
April 2024
Primary completion
February 2026
This trial's estimated completion date has passed — the record may not be fully up to date.
Age range
18 Years – 90 Years
Last updated on clinicaltrials.gov in April 2025.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Rahul Krishnatry, MD
Tata Memorial Centre
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.