Study of Sotorasib, Panitumumab and FOLFIRI Versus FOLFIRI With or Without Bevacizumab-awwb in Treatment-naïve Participants With Metastatic Colorectal Cancer With KRAS p.G12C Mutation — Stella
Phase 3 — Large-scale testing across thousands of people, comparing the new treatment against current standard treatments.
(286 sites) United States
Ironwood Cancer and Research Centers Scottsdale, Chandler, Arizona Providence Saint Jude Medical Center, Fullerton, California City of Hope National Medical Center, Long Beach, California Cancer and Blood Research Center, LLC, Los Alamitos, California California Research Institute, Los Angeles, California Norwalk Hospital, Norwalk, Connecticut Cancer Specialists of North Florida - Southpoint, Jacksonville, Florida D and H Cancer Research Center, Margate, Florida Mid Florida Hematology and Oncology Centers PA, Orange City, Florida Boca Raton Clinical Research Medical Center Inc, Plantation, Florida Georgia Cancer Specialists, Atlanta, Georgia Insight Research Institute, Chicago, Illinois Hope and Healing Cancer Services, Hinsdale, Illinois Orchard Healthcare Research Inc, Skokie, Illinois Pikeville Medical Center, Pikeville, Kentucky Henry Ford Health System, Detroit, Michigan Cancer and Hematology Centers of Western Michigan, Grand Rapids, Michigan Saint Louis Cancer Care West County, Bridgeton, Missouri Minniti Center for Medical Oncology and Hematology, Mickleton, New Jersey Duke Cancer Center, Durham, North Carolina FirstHealth Cancer Center, Pinehurst, North Carolina Thomas Jefferson University, Philadelphia, Pennsylvania Carolina Blood and Cancer Care, Rock Hill, South Carolina Tennessee Oncology PLLC - Chattanooga, Nashville, Tennessee Tennessee Oncology, PLLC, Nashville, Tennessee Vanderbilt University Medical Center, Nashville, Tennessee Argentina
Hospital Universitario Fundacion Favaloro, CABA, Buenos Aires Instituto Argentino de Diagnóstico y Tratamiento, CABA, Buenos Aires Investigaciones Clinicas Moleculares - Centro de Endocrinologia y Diabetes Dr Raul Gutman SRL, CABA, Buenos Aires Cemic, Ciudad Autonoma de Buenos Aires, Buenos Aires Sanatorio Británico de Rosario, La Plata, Buenos Aires Instituto de Investigaciones clinicas de Mar del Plata, Mar del Plata, Buenos Aires Hospital Italiano de Córdoba, Córdoba, Córdoba Province Sanatorio Allende, Córdoba, Córdoba Province Clinica Universitaria Privada Reina Fabiola, Córdoba, Córdoba Province Clinica Viedma, Viedma, Río Negro Province Exelsus Oncologia Clinica, San Miguel de Tucumán, Tucumán Province Hospital Britanico de Buenos Aires, Buenos Aires Australia
Chris OBrien Lifehouse, Camperdown, New South Wales Toowoomba Hospital, Toowoomba, Queensland Princess Alexandra Hospital, Woolloongabba, Queensland Flinders Medical Centre, Bedford Park, South Australia The Queen Elizabeth Hospital, Woodville South, South Australia Austin Health, Austin Hospital, Heidelberg, Victoria Austria
Medizinische Universitaet Graz, Graz Ordensklinikum Linz Barmherzige Schwestern, Linz Landeskrankenhaus Feldkirch, Rankweil Universitaetsklinikum Allgemeines Krankenhaus Wien, Vienna Krankenhaus Wiener Neustadt, Wiener Neustadt Belgium
Universite Catholique de Louvain Cliniques Universitaires Saint Luc, Brussels Institut Jules Bordet, Brussels Grand Hôpital de Charleroi - Site des Viviers, Charleroi Universitair Ziekenhuis Gent, Ghent Universitair Ziekenhuis Leuven - Campus Gasthuisberg, Leuven Algemeen Ziekenhuis Sint Maarten-Emmaus vzw, Mechelen AZ Delta Campus Rumbeke, Roeselare Vitaz campus Sint-Niklaas Moerland, Sint-Niklaas Brazil
Hospital Evangelico de Cachoeiro de Itapemirim, Cachoeiro de Itapemirim, Espírito Santo Hospital Sirio Libanes Brasilia, Brasília, Federal District Vencer e Oncoclinica, Teresina, Piauí Liga Norte-Riograndense Contra O Cancer, Natal, Rio Grande do Norte Oncosite Centro de Pesquisa Clinica Em Oncologia Ltda, Ijuí, Rio Grande do Sul Irmandade da Santa Casa de Misericordia de Porto Alegre, Porto Alegre, Rio Grande do Sul Associação Hospitalar Moinhos de Vento, Porto Alegre, Rio Grande do Sul Clinica de Neoplasias Litoral, Itajaí, Santa Catarina Fundacao pio xII Barretos, Barretos, São Paulo Oncoclinicas Belo Horizonte, Barretos, São Paulo Hospital de Base de Sao Jose do Rio Preto, São José do Rio Preto, São Paulo Fundacao Antonio Prudente AC Camargo Cancer Center, São Paulo, São Paulo Bulgaria
Specialized Hospital for Active Treatment of Oncology - Haskovo EOOD, Haskovo Multiprofile Hospital for Active Treatment Central Onco Hospital OOD, Plovdiv Complex Oncology Center Plovdiv EOOD, Plovdiv Military Medical Academy Multiprofile Hospital for Active Treatment - Sofia, Sofia Multiprofile Hospital for Active Treatment Serdikamed EOOD, Sofia Canada
Arthur J E Child Comprehensive Cancer Centre, Calgary, Alberta William Osler Health System - Brampton Civic Hospital, Brampton, Ontario Sunnybrook Research Institute Sunnybrook Health Sciences Centre, Toronto, Ontario Allan Blair Cancer Centre, Regina, Saskatchewan Saskatoon Cancer Centre, Saskatoon, Saskatchewan Chile
James Lind Centro de Investigacion del Cancer, Temuco, Cautín Centro de investigacion y desarrollo oncolgico Spa, Temuco, Cautín Enroll SpA, Providencia, Santiago Metropolitan Clinica Redsalud Vitacura, Instituto del Cancer, Vitacura, Santiago Metropolitan Fundacion Arturo Lopez Perez, Santiago Centro de oncologia de precision Spa, Santiago Biocinetic servicios medicos limitada, Santiago Clinical Research Chile SpA, Valdivia Colombia
Servicios de Salud Ips Suramericana Sas - Ips Sura Industriales, Medellín, Antioquia Institucion Prestadora de Servicios de Salud Sociedad Médica Rionegro SA Somer SA, Rionegro, Antioquia Instituto Nacional de Cancerologia, Bogota, Cundinamarca Centro de Tratamiento e Investigación sobre Cancer Luis Carlos Sarmiento Angulo Ctic, Bogotá, Cundinamarca Instituto Medico de Alta Tecnologia sas - Imat sas, Montería, Departamento de Córdoba Fundacion Oftalmologica de Santander - Foscal, Floridablanca, Santander Department Czechia
Masarykuv onkologicky ustav, Brno Fakultni nemocnice Hradec Kralove, Hradec Králové Fakultni nemocnice Olomouc, Olomouc Fakultni nemocnice Kralovske Vinohrady, Prague Fakultni nemocnice v Motole, Prague Fakultni nemocnice Bulovka, Prague Denmark
Aarhus University Hospital, Aarhus N Rigshospitalet, Copenhagen Odense University Hospital, Odense C Estonia
North Estonia Medical Centre Foundation, Tallinn France
Centre Hospitalier Universitaire de Clermont Ferrand - Hopital Estaing, Clermont-Ferrand Hopital Henri Mondor, Créteil Centre Hospitalier Universitaire de Dijon - Hopital du Bocage, Dijon Hopital Prive Jean Mermoz, Lyon Institut regional du Cancer Montpellier, Montpellier Centre Antoine Lacassagne, Nice Hopital Europeen Georges Pompidou, Paris Hopital Saint Louis, Paris Hopital Pitie-Salpetriere, Paris Centre Hospitalier Universitaire de Bordeaux - Hopital Haut Leveque, Pessac Centre Hospitalier Universitaire de Poitiers, Poitiers Hopital Robert Debre, Reims Centre Hospitalier Universitaire de Rennes - Hopital Pontchaillou, Rennes
Germany
Charite - Universitaetsmedizin Berlin, Campus Virchow, Berlin Klinikum Chemnitz gGmbH, Chemnitz Universitaetsklinikum Dresden, Dresden Universitaetsklinikum Essen, Essen UCT Universitaeres Zentrum fuer Tumorerkrankungen Frankfurt, Frankfurt am Main Haematologisch Onkologische Praxis Eppendorf, Hamburg Regional Kliniken Holding Klinikum Ludwigsburg, Ludwigsburg Klinikum der LMU Muenchen, München Universitaetsklinikum Ulm, Ulm Klinikum der Stadt Wolfsburg, Wolfsburg Greece
General Hospital Evangelismos, Athens Agios Savvas Anticancer Hospital, Athens Athens Medical Center S.A - Psychikon, Athens Aretaieio Hospital, Athens Metropolitan Hospital, Athens University Hospital of Larissa, Larissa Metaxa Anticancer Hospital, Piraeus Bioclinic of Thessaloniki, Thessaloniki Saint Luke Hospital, Thessaloniki Saint Lukes Hospital SA, Thessaloniki European Interbalkan Medical Center, Thessaloniki Hong Kong
Queen Mary Hospital, The University of Hong Kong, Hong Kong Princess Margaret Hospital, Kowloon Tuen Mun Hospital, New Territories Hungary
Orszagos Onkologiai Intezet, Budapest Debreceni Egyetem Klinikai Kozpont, Debrecen Bekes Varmegyei Kozponti Korhaz Pandy Kalman Tagkorhaz, Gyula Somogy Varmegyei Kaposi Mor Oktato Korhaz, Kaposvár Szabolcs-Szatmar-Bereg Varmegyei Oktatokorhaz Nyiregyhazi Josa Andras Tagkorhaz, Nyíregyháza Jasz-Nagykun-Szolnok Varmegyei Hetenyi Geza Korhaz-Rendelointezet, Szolnok Italy
Istituto Ospedaliero Fondazione Poliambulanza, Brescia Ente Ospedaliero IRCCS Saverio De Bellis, Castellana Grotte Azienda Ospedaliero Universitaria Careggi, Florence Azienda Ospedaliero Universitaria Ospedali Riuniti di Foggia, Foggia Ospedale Policlinico San Martino IRCCS, Genova Istituto Romagnolo per lo Studio dei Tumori Dino Amadori, Meldola FC Fondazione IRCCS Istituto Nazionale dei Tumori, Milan Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda, Milan Azienda Ospedaliera di Rilievo Nazionale Specialistica dei Colli Monaldi, Naples Istituto Nazionale dei Tumori IRCCS Fondazione Giovanni Pascale, Naples Istituto Oncologico Veneto IRCCS, Padova Azienda di Rilievo Nazionale e Alta Specializzazione Civico Di Cristina Benfratelli, Palermo Japan
Aichi Cancer Center, Nagoya, Aichi-ken Chiba Cancer Center, Chiba, Chiba National Cancer Center Hospital East, Kashiwa-shi, Chiba National Hospital Organization Shikoku Cancer Center, Matsuyama, Ehime National Hospital Organization Kyushu Cancer Center, Fukuoka, Fukuoka Hokkaido University Hospital, Sapporo, Hokkaido Hyogo Cancer Center, Akashi-shi, Hyōgo St Marianna University Hospital, Kawasaki-shi, Kanagawa Yokohama City University Medical Center, Yokohama, Kanagawa Kanagawa Prefectural Hospital Organization Kanagawa Cancer Center, Yokohama, Kanagawa Niigata Cancer Center Hospital, Niigata, Niigata Kansai Medical University Hospital, Hirakata-shi, Osaka National Hospital Organization Osaka National Hospital, Osaka, Osaka Mexico
Centro Especializado en Investigacion y Tratamiento Oncologicos SC, Benito Juárez, Mexico City Health Pharma Professional Research SA de CV, Mexico City, Mexico City Hospital Universitario Dr Jose Eleuterio Gonzalez, Monterrey, Nuevo León Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City Netherlands
Nederlands Kanker Instituut - Antoni van Leeuwenhoek, Amsterdam Albert Schweitzer Ziekenhuis, Locatie Dordwijk, Dordrecht Medisch Spectrum Twente, Enschede Martini Ziekenhuis, Groningen Maastricht Universitair Medisch Centrum, Maastricht Universitair Medisch Centrum Utrecht, Utrecht Poland
Szpitale Pomorskie spolka z ograniczona odpowiedzialnoscia, Gdynia Swietokrzyskie Centrum Onkologii Samodzielny Publiczny Zaklad Opieki Zdrowotnej w Kielcach, Kielce Wojewodzkie Wielospecjalistyczne Centrum Onkologii i Traumatologii im M Kopernika w Lodzi, Lodz SPZOZ Opolskie Centrum Onkologii imienia prof Tadeusza Koszarowskiego w Opolu, Opole Wielkopolskie Centrum Onkologii imienia Marii Sklodowskiej-Curie, Poznan Narodowy Instytut Onkologii im Marii Sklodowskiej-Curie - Panstwowy Instytut Badawczy, Warsaw Panstwowy Instytut Medyczny Ministerstwa Spraw Wewnetrznych i Administracji, Warsaw Wojskowy Instytut Medyczny - Panstwowy Instytut Badawczy, Warsaw Portugal
Unidade Local de Saude de Almada-Seixal, EPE - Hospital Garcia de Orta, Almada Instituto Portugues de Oncologia de Coimbra Francisco Gentil, EPE, Coimbra Unidade Local de Saude de Coimbra, EPE, Coimbra Hospital Cuf Tejo, Lisbon Fundacao Champalimaud, Lisbon Hospital da Luz, SA, Lisbon Unidade Local de Saude de Santa Maria, EPE - Hospital de Santa Maria, Lisbon Unidade Local de Saude de Matosinhos, EPE - Hospital Pedro Hispano, Matosinhos Municipality Unidade Local de Saude de Entre Douro e Vouga, EPE - Hospital de Sao Sebastiao, Santa Maria da Feira Romania
Institutul Clinic Fundeni, Bucharest Institutul Oncologic Prof Dr Alexandru Trestioreanu Bucuresti, Bucharest Institutul Oncologic Prof Dr Ion Chiricuta Cluj-Napoca, Cluj-Napoca Centrul de Oncologie Sf Nectarie SRL, Craiova Institutul Regional de Oncologie Iasi, Iași Spitalul Municipal Ploiesti, Ploieşti SC Oncomed SRL, Timișoara South Korea
National Cancer Center, Goyang-si, Gyeonggi-do Korea University Anam Hospital, Seoul Seoul National University Hospital, Seoul Severance Hospital Yonsei University Health System, Seoul Samsung Medical Center, Seoul The Catholic University of Korea Seoul St Marys Hospital, Seoul Korea University Guro Hospital, Seoul Asan Medical Center, Seoul Spain
Hospital Universitario Reina Sofia, Córdoba, Andalusia Hospital Universitario Virgen de las Nieves, Granada, Andalusia Hospital Regional Universitario de Malaga, Málaga, Andalusia Hospital Universitario Virgen del Rocio, Seville, Andalusia Hospital Universitario Miguel Servet, Zaragoza, Aragon Hospital Universitario Marques de Valdecilla, Santander, Cantabria Hospital Universitario de Burgos, Burgos, Castille and León Institut Catala d Oncologia Badalona Hospital Universitari Germans Trias i Pujol, Badalona, Catalonia Hospital Universitari Vall d Hebron, Barcelona, Catalonia Hospital de la Santa Creu i Sant Pau, Barcelona, Catalonia Institut Catala d Oncologia Hospitalet Hospital Duran i Reynals, L'Hospitalet de Llobregat, Catalonia Complexo Hospitalario Universitario de Ourense, Ourense, Galicia
Sweden
Soedersjukhuset, Stockholm Switzerland
Universitaetsspital Zuerich, Zurich Taiwan
China Medical University Hospital, Taichung Taichung Veterans General Hospital, Taichung Taipei Veterans General Hospital, Taipei Linkou Chang Gung Memorial Hospital of Chang Gung Medical Foundation, Taoyuan District Thailand
Siriraj Hospital, Bangkok Turkey (Türkiye)
Adana Sehir Egitim ve Arastirma Hastanesi, Adana Hacettepe Universitesi Tip Fakultesi Hastanesi, Ankara Gazi Universitesi Saglik Arastirma ve Uygulama Merkezi Gazi Hastanesi, Ankara Ankara Universitesi Tip Fakultesi Hastanesi, Ankara Ankara Bilkent Sehir Hastanesi, Ankara Trakya Universitesi Saglik Arastirma ve Uygulama Merkezi, Edirne Bezmialem Vakif Universitesi Hastanesi, Istanbul Bagcilar Medipol Mega Universite Hastanesi, Istanbul Acibadem Altunizade Hastanesi, Istanbul Kartal Dr Lutfi Kirdar Sehir Hastanesi, Istanbul Ege Universitesi Tip Fakultesi Hastanesi, Izmir Necmettin Erbakan Universitesi Tip Fakultesi Hastanesi, Konya Inonu Universitesi Turgut Ozal Tip Merkezi, Malatya United Kingdom
Queen Elizabeth Hospital Birmingham, Birmingham Beatson West of Scotland Cancer Centre, Glasgow Royal Free Hospital, London Royal Marsden Hospital, London Sarah Cannon Research Institute UK, London Maidstone Hospital, Maidstone Mount Vernon Cancer Centre, Northwood Weston Park Hospital, Sheffield Royal Marsden Hospital - Sutton, Sutton
Key details Enrollment target
~450 participants
Primary completion
January 2028
Age range
18 Years and older
Last updated April 2026
Interested in joining? Centro Oncologico Riojano Integral, La Rioja
Oncoclinicas Rio de Janeiro S A, Rio de Janeiro
Instituto Cancer Sao Paulo Icesp, São Paulo Instituto Brasileiro de Controle do Cancer Ibcc, São Paulo Oncologia Rede D Or, São Paulo Institut de Cancerologie de l Ouest Rene Gauducheau, Saint-Herblain
Centre Hospitalier Universitaire Nord de Saint Etienne - Hopital Nord, Saint-Priest-en-Jarez Institut de Cancerologie de Lorraine, Vandœuvre-lès-Nancy Azienda Sanitaria Territoriale Pesaro Urbino - Presidio San Salvatore Muraglia, Pesaro
Azienda Ospedaliero Universitaria Pisana, Pisa Azienda Unità Sanitaria Locale della Romagna Presidio ospedaliero di Ravenna, Ravenna IRCCS Istituto Clinico Humanitas, Rozzano MI Fondazione IRCCS Ospedale Casa Sollievo della Sofferenza, San Giovanni Rotondo Azienda Sanitaria Universitaria Friuli Centrale Presidio Ospedaliero Santa Maria della Misericordia, Udine Azienda Ospedaliera Universitaria Integrata di Verona Ospedale Civile Maggiore Borgo Trento, Verona The University of Osaka Hospital, Suita-shi, Osaka Saitama Cancer Center, Kitaadachi-gun, Saitama Shizuoka Cancer Center, Sunto-gun, Shizuoka Tokushima University Hospital, Tokushima, Tokushima National Cancer Center Hospital, Chuo-ku, Tokyo The Cancer Institute Hospital of Japanese Foundation for Cancer Research, Koto-ku, Tokyo Hospital Universitario de Navarra, Pamplona, Navarre
Hospital Universitario Central de Asturias, Oviedo, Principality of Asturias Hospital General Universitario de Elche, Elche, Valencia Hospital Clinico Universitario de Valencia, Valencia, Valencia Hospital General Universitario de Valencia, Valencia, Valencia Hospital General Universitario Gregorio Maranon, Madrid Hospital Universitario 12 de Octubre, Madrid Hospital Universitario La Paz, Madrid